This protocol provides a targeted neuroimmune support framework for PANS/PANDAS, focusing on immune signaling balance, gut–brain axis integrity, and oxidative stress regulation. By addressing Th17/Treg modulation, microbial triggers, glutathione-dependent antioxidant defenses, and neuroimmune activation, the strategy is designed to promote nervous system stability, sensory balance, and overall neurological resilience within a comprehensive care model.